Examination of the effect of increasing the number of radiation beams on a radiation treatment plan

Phys Med Biol. 2002 Oct 7;47(19):3485-501. doi: 10.1088/0031-9155/47/19/304.

Abstract

Within the confines of least-squares operations, it is possible to quantify the effect of the addition of treatment fields or beamlets to a treatment plan. Using linear algebra and eigenvalue perturbation theory, the effect of the increase in number of treatments is shown to be equivalent to adding a perturbation operator. The effect of adding additional fields will be negligible if the perturbation operator is small. The correspondence of this approach to an earlier work in beam-orientation optimization is also demonstrated. Results are presented for prostate, spinal and head and neck cases, and the connection to beam-orientation optimization is examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dose-Response Relationship, Radiation
  • Head and Neck Neoplasms / radiotherapy
  • Humans
  • Male
  • Models, Statistical
  • Models, Theoretical
  • Prostatic Neoplasms / radiotherapy
  • Radiotherapy / methods*
  • Radiotherapy Planning, Computer-Assisted / methods*