Abstract
Mutations at reverse transcriptase codons 44, 118, 207, and 208 were significantly correlated with reduced zidovudine susceptibility in biologically cloned human immunodeficiency virus type 1 (HIV-1) isolates. Sequences from the Stanford HIV RT and Protease Sequence Database showed that these mutations were more common in HIV-1 isolates from patients treated with zidovudine and lamivudine than in patients not treated with these drugs.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Clone Cells
-
Drug Resistance, Viral / genetics*
-
Genotype
-
HIV Infections / drug therapy
-
HIV Infections / virology
-
HIV-1 / drug effects
-
HIV-1 / genetics*
-
HIV-1 / isolation & purification
-
Humans
-
Lamivudine / pharmacology*
-
Lamivudine / therapeutic use
-
Molecular Sequence Data
-
Mutation*
-
Phenotype
-
Reverse Transcriptase Inhibitors / pharmacology*
-
Reverse Transcriptase Inhibitors / therapeutic use
-
Zidovudine / pharmacology*
-
Zidovudine / therapeutic use
Substances
-
Reverse Transcriptase Inhibitors
-
Lamivudine
-
Zidovudine
Associated data
-
GENBANK/AY013828
-
GENBANK/AY013868