Antioxidative 7-oxodehydropodocarpane-type trinorditerpenes from the bark of Taiwania cryptomerioides

Planta Med. 2002 Nov;68(11):1020-3. doi: 10.1055/s-2002-35648.

Abstract

Five new 7-oxopodocarpane-type trinorditerpenes together with 1beta,13,14-trihydroxy-8,11,13-podocarpatrien-7-one ( 1) were isolated from the bark of Taiwania cryptomerioides. By using NMR and other spectral methods, the structures of five new compounds, 14-hydroxy-13-methoxy-8,11,13-podocarpatriene-3,7-dione ( 2), 1beta,14-dihydroxy-13-methoxy-8,11,13-podocarpatrien-7-one ( 3), 13,14-dihydroxy-8,11,13-podocarpatriene-3,7-dione ( 4), 3beta,13,14-trihydroxy-8,11,13-podocarpatrien-7-one ( 5), and 1beta,13,14-trihydroxy-8,11,13-podocarpatriene-2,7-dione ( 6), were elucidated. Compounds 1, 4, 5, and 6 exhibited strong antioxidative activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Biphenyl Compounds
  • Cupressaceae*
  • Diterpenes / chemistry
  • Diterpenes / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Phytotherapy*
  • Picrates
  • Plant Bark
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*

Substances

  • Antioxidants
  • Biphenyl Compounds
  • Diterpenes
  • Picrates
  • Plant Extracts
  • 1,1-diphenyl-2-picrylhydrazyl