Suppression of Helicobacter pylori-induced interleukin-8 production in gastric cancer cell lines by an anti-ulcer drug, geranylgeranylacetone

J Gastroenterol Hepatol. 2002 Nov;17(11):1153-60. doi: 10.1046/j.1440-1746.2002.02880.x.

Abstract

Background: Geranylgeranylacetone (GGA) is an antigastritis and anti-ulcer agent, with as yet an unknown mechanism of action. In this study, we investigated the effect of GGA on Helicobacter pylori-induced interleukin (IL)-8 production and IL-8 mRNA expression in KATOIII cells, an established gastric cell line.

Methods: Interleukin-8 production in H. pylori-infected KATOIII cells was measured by using enzyme-linked immunoassay. The cytotoxicity of H. pylori on KATOIII cells was measured by a 51Cr release assay. The effect of GGA on H. pylori-induced IL-8 mRNA expression was measured by using northern blotting.

Results: Interleukin-8 production increased with time and H. pylori dose; the most significant increase was seen within 6-24 h of coculture with H. pylori. A dose of 0.1 mmol GGA suppressed IL-8 production (P = 0.0077) and inhibited H. pylori-induced IL-8 mRNA expression (P = 0.0019). Furthermore, H. pylori-induced gastric mucosal cell injury associated with IL-8 and neutrophil activation was enhanced by NH3, and this enhancement was suppressed by GGA (P = 0.0043).

Conclusions: Helicobacter pylori-infected gastric mucosal cells produce IL-8, which can promote neutrophil activation, thus contributing to mucosal tissue injury associated with H. pylori infection. Agents like GGA, which can suppress IL-8 production may have a protective role in the treatment of mucosal tissue damage seen in H. pylori infection.

MeSH terms

  • Analysis of Variance
  • Anti-Ulcer Agents / pharmacology*
  • Blotting, Northern
  • Diterpenes / pharmacology*
  • Enzyme-Linked Immunosorbent Assay
  • Helicobacter pylori / physiology*
  • Humans
  • Interleukin-8 / metabolism*
  • Neutrophil Activation
  • RNA, Messenger / biosynthesis
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / microbiology
  • Tumor Cells, Cultured

Substances

  • Anti-Ulcer Agents
  • Diterpenes
  • Interleukin-8
  • RNA, Messenger
  • geranylgeranylacetone