Using B-mode transcranial sonography (TCS), it is possible to image the brain parenchyma through the intact skull with conventional low-frequency probes. Several brain disorders can be depicted by TCS such as bleedings, brain tumors, or enlargement of the ventricular system. More recently there is evidence that TCS findings can complement information from other neuroimaging techniques in neurodegenerative disorders leading to new insights and pathophysiological concepts.