The assessment of IgG avidity in the evaluation of perinatal herpes simplex virus infection

Marie-Hélène Odièvre; Denis Cointe; Bernard Thébaud; Véronique Zupan; Didier Ingrand; Thierry Lacaze-Masmonteil; Liliane Grangeot-Keros

doi:10.1038/sj.jp.7210781

The assessment of IgG avidity in the evaluation of perinatal herpes simplex virus infection

J Perinatol. 2002 Dec;22(8):669-71. doi: 10.1038/sj.jp.7210781.

Authors

Marie-Hélène Odièvre¹, Denis Cointe, Bernard Thébaud, Véronique Zupan, Didier Ingrand, Thierry Lacaze-Masmonteil, Liliane Grangeot-Keros

Affiliation

¹ Service de Pédiatrie et Réanimation Néonatales, Hôpital Antoine-Béclère, Assistance Publique/Hôpitaux de Paris, Clamart, France.

PMID: 12478453
DOI: 10.1038/sj.jp.7210781

Abstract

Classical serologic assays are not useful for the diagnosis of perinatal herpes simplex virus (HSV) infection during the acute phase of the disease. We report two cases of neonatal HSV infection that highlight the diagnostic value of HSV-specific IgG avidity and its contribution for further characterization of neonatal HSV infection.

Publication types

Case Reports

MeSH terms

Antibody Affinity / physiology*
Female
Herpes Simplex / blood*
Herpes Simplex / physiopathology*
Humans
Immunoglobulin G / blood*
Immunoglobulin G / physiology*
Infant, Newborn
Male
Simplexvirus / isolation & purification
Simplexvirus / physiology*

Substances

Immunoglobulin G