Stereoselective transition metal-catalyzed and radical polycyclizations

Curr Opin Drug Discov Devel. 2002 Nov;5(6):928-36.

Abstract

This short review presents a selection of metal-mediated and radical polycyclizations reported during the past two years. Palladium-catalyzed domino processes, cobalt-mediated cycloadditions and Pauson-Khand reactions catalyzed by rhodium are described. Ruthenium and platinum are shown as powerful metal catalysts in cyclizations, ring-closing metathesis and cycloisomerizations. Finally, recent examples of radical cascades, and their synthetic applications, are selected for their ability to build polycyclic compounds.

Publication types

  • Review

MeSH terms

  • Animals
  • Catalysis / drug effects
  • Free Radicals / chemistry
  • Free Radicals / metabolism
  • Humans
  • Metals / chemistry
  • Metals / metabolism*
  • Polycyclic Compounds / chemistry
  • Polycyclic Compounds / metabolism*
  • Stereoisomerism
  • Technology, Pharmaceutical / methods*

Substances

  • Free Radicals
  • Metals
  • Polycyclic Compounds