Preparation of [11C] radioligands with high specific radioactivity on a commercial PET tracer synthesizer

Nucl Med Biol. 2003 Jan;30(1):79-83. doi: 10.1016/s0969-8051(02)00353-0.

Abstract

High specific radioactivity is required for receptor studies with PET. Hereby we wish to report our experience using Nuclear Interface PET Tracer Synthesizer for preparation of Carbon-11 radioligands and module's modifications, which allowed to achieve high specific radioactivity.

Publication types

  • Comparative Study
  • Evaluation Study
  • Validation Study

MeSH terms

  • Carbon Dioxide / chemistry
  • Carbon Radioisotopes / chemistry*
  • Carbon Radioisotopes / isolation & purification
  • Equipment Design
  • Isotope Labeling / instrumentation*
  • Isotope Labeling / methods*
  • Ligands
  • Quality Control
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / isolation & purification
  • Reproducibility of Results
  • Tomography, Emission-Computed / instrumentation
  • Tomography, Emission-Computed / methods*

Substances

  • Carbon Radioisotopes
  • Ligands
  • Radiopharmaceuticals
  • Carbon Dioxide