Penetration of capecitabine and its metabolites into malignant and healthy tissue of patients with advanced breast cancer

Int J Clin Pharmacol Ther. 2002 Dec;40(12):571-2. doi: 10.5414/cpp40571.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Antimetabolites, Antineoplastic / metabolism
  • Antimetabolites, Antineoplastic / pharmacokinetics*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Capecitabine
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / metabolism
  • Deoxycytidine / pharmacokinetics*
  • Deoxycytidine / therapeutic use
  • Electrophoresis, Capillary
  • Extracellular Space / metabolism
  • Floxuridine / metabolism
  • Fluorouracil / analogs & derivatives
  • Humans
  • Prodrugs / metabolism
  • Prodrugs / pharmacokinetics*
  • Prodrugs / therapeutic use
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / secondary
  • Tissue Distribution

Substances

  • Antimetabolites, Antineoplastic
  • Prodrugs
  • Floxuridine
  • Deoxycytidine
  • Capecitabine
  • 5'-deoxy-5-fluorocytidine
  • Fluorouracil
  • doxifluridine