Scotoma size and reading speed in patients with subfoveal occult choroidal neovascularization in age-related macular degeneration

Ophthalmology. 2003 Jan;110(1):65-9. doi: 10.1016/s0161-6420(02)01566-x.

Abstract

Purpose: To investigate the correlation between reading speed and scotoma size in patients with subfoveal occult with no classic choroidal neovascularization (CNV) in age-related macular degeneration (AMD) participating at 2 of 28 centers in the Verteporfin in Photodynamic Therapy trial.

Design: Prospective, observational case series.

Participants: Twenty-two eyes of 22 patients with occult with no classic CNV in AMD.

Methods: Patients' reading speed was examined using a German-language reading test (Radner Lesetest). Scotoma size was measured using the microperimetry program 2.01 of the Rodenstock Scanning Laser Ophthalmoscope.

Main outcome measures: Reading acuity, reading speed, size of absolute (AS) and relative scotoma (RS).

Results: There was a significant correlation between the size of AS and reading speed (r = -0.48, P = 0.023), as well as AS and reading acuity (r = 0.52, P = 0.013). No correlation was seen between RS and reading speed or reading capacity.

Conclusion: The size of absolute scotoma correlated significantly with reading capacity and reading speed and may influence these measures.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Aged
  • Choroidal Neovascularization / drug therapy
  • Choroidal Neovascularization / etiology*
  • Choroidal Neovascularization / physiopathology
  • Female
  • Fovea Centralis / pathology*
  • Humans
  • Macular Degeneration / complications*
  • Macular Degeneration / drug therapy
  • Macular Degeneration / physiopathology
  • Male
  • Photochemotherapy
  • Photosensitizing Agents / therapeutic use
  • Porphyrins / therapeutic use
  • Prospective Studies
  • Reading*
  • Scotoma / etiology
  • Scotoma / pathology*
  • Scotoma / physiopathology
  • Verteporfin
  • Visual Acuity
  • Visual Field Tests
  • Visual Fields

Substances

  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin