The fluorapatite-anorthite system in biomedicine

Biomaterials. 2003 Mar;24(7):1317-31. doi: 10.1016/s0142-9612(02)00468-4.

Abstract

Glasses and glass ceramics of fluorapatite-anorthite (eutectic composition) were produced and characterized in order to evaluate their potential application in biomedicine. Bio-reactivity was determined by in vitro tests by immersion of powders in simulated plasma liquids as well as by in vivo experiments by implantation in rabbits. According to the results, the investigated materials are bio-acceptable since no toxic or other harmful evidence was detected. Glass-ceramics showed remarkable inertness, whereas glasses spontaneously dissolved in SBF and after 1 week moderate formation of apatite was observed, that however ceased within a month.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum Silicates* / chemistry*
  • Aluminum Silicates* / metabolism
  • Animals
  • Apatites / chemistry*
  • Apatites / metabolism
  • Biocompatible Materials / chemistry*
  • Ceramics / chemistry*
  • Glass*
  • In Vitro Techniques
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Rabbits

Substances

  • Aluminum Silicates
  • Apatites
  • Biocompatible Materials
  • anorthite
  • fluorapatite