Comprehensive intervention measures for preventing cardio-cerebro-vascular diseases of community population were carried out in Beijing, Shanghai and Changsha urban areas, and then was evaluated to its effects on knowledge, attitude and behavior (KAB) levels and health-related behaviors of population by quasi-trial designation. Results showed that the net KAB leveling were separately 9.89 in 1995, 4.74 in 1997 and 10.66 in 2000 in comparison with base investigation, and statistically significant difference was found. Of 6 health-related behaviors, caring to health knowledge, being influenced by health knowledge and exercising were significantly influenced, next controlling salt consumption. No change of smoking and alcohol drinking was found. Among different target population, these changes among women were higher than man as well as at home or retired than at work, and hypertension than normtension. As aging and education time decreasing, both absolute and relative effects of health education were better. It suggests that comprehensive intervention with health education as its main measure promote KAB levels and transfer health-related behaviors of population. It is great important to preventing cardio-cerebro-vascular diseases of community population.