Objective: To study the relationship between the expression of MRP mRNA and the clinical pathological characteristics of the patients with laryngeal squamous cell carcinoma.
Method: Reverse transcription polymerase chain reaction (RT-PCR) assay was used to detect the expression of MRP mRAN in 35 patients.
Result: The positive expression rate of MRP mRAN was 45.7 percent (16/35) in laryngeal carcinoma. It was higher in advanced (T3-4) patients than that in early (T1-2) cases (P < 0.05) and showed a significant correlation with metastases of cervical lymph node (P < 0.01).
Conclusion: It is suggested that the expression of MRP mRNA may not only play an important role in multidrug resistance of laryngeal carcinoma, but also influence their biological behavior of dissemination and metastases.