Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis

Planta Med. 2003 Jan;69(1):63-4. doi: 10.1055/s-2003-37024.

Abstract

Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC 50 : 1.33 +/- 0.05 microM) and schisandrol A (IC 50 : 1.34 +/- 0.05 microM) showed higher activity than gomisin E (IC 50 : 4.73 +/- 0.09 microM), schisandrin A (IC 50 : 7.23 +/- 0.21 microM), schisandrin C (IC 50 : 7.54 +/- 0.22 microM), benzoylisogomisin O (IC 50 : 11.06 +/- 1.02 microM) and schisandrol B (IC 50 : 16.37 +/- 1.00 microM).

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA-Binding Proteins / antagonists & inhibitors*
  • Humans
  • Jurkat Cells
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • NFATC Transcription Factors
  • Nuclear Proteins*
  • Schisandra / chemistry*
  • Transcription Factors / antagonists & inhibitors*

Substances

  • DNA-Binding Proteins
  • Lignans
  • NFATC Transcription Factors
  • Nuclear Proteins
  • Transcription Factors