Abstract
The authors compared the functional activation state and cytokine secretion profile of CD8+ T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in normal controls. In addition, they examined cytokine secretion in relationship to single nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with SPMS as compared to normal controls. The authors found no significant differences in SNP frequency or in secretion of other cytokines.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antibodies / pharmacology
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CD3 Complex / immunology
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CD8-Positive T-Lymphocytes / drug effects
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / metabolism
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Cell Division / drug effects
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Cell Division / immunology
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Cell Separation
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Cells, Cultured
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Cytokines / immunology
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Cytokines / metabolism
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Female
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Flow Cytometry
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Gene Frequency
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Humans
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Lymphotoxin-alpha / genetics
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Lymphotoxin-alpha / immunology*
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Lymphotoxin-alpha / metabolism
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Male
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Middle Aged
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Multiple Sclerosis, Chronic Progressive / genetics
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Multiple Sclerosis, Chronic Progressive / immunology*
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Multiple Sclerosis, Relapsing-Remitting / genetics
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Multiple Sclerosis, Relapsing-Remitting / immunology
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Polymorphism, Single Nucleotide
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Reference Values
Substances
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Antibodies
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CD3 Complex
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Cytokines
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Lymphotoxin-alpha