t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

Genes Chromosomes Cancer. 2003 Apr;36(4):402-5. doi: 10.1002/gcc.10174.

Abstract

Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML.

Publication types

  • Case Reports

MeSH terms

  • Acetyltransferases / genetics*
  • Aged
  • Aged, 80 and over
  • CREB-Binding Protein
  • Chromosomes, Human, Pair 10 / genetics*
  • Chromosomes, Human, Pair 16 / genetics*
  • Cytogenetic Analysis / methods
  • Fatal Outcome
  • Histone Acetyltransferases
  • Humans
  • Leukemia, Monocytic, Acute / diagnosis
  • Leukemia, Monocytic, Acute / genetics*
  • Male
  • Neoplasm Recurrence, Local / genetics
  • Nuclear Proteins / genetics*
  • Oncogene Proteins, Fusion / genetics*
  • Saccharomyces cerevisiae Proteins / genetics*
  • Trans-Activators / genetics*
  • Translocation, Genetic / genetics

Substances

  • Nuclear Proteins
  • Oncogene Proteins, Fusion
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • Acetyltransferases
  • CREB-Binding Protein
  • CREBBP protein, human
  • Histone Acetyltransferases