Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intrathecal vancomycin in an allogeneic peripheral blood stem cell transplant recipient

Bone Marrow Transplant. 2003 Jan;31(1):65-7. doi: 10.1038/sj.bmt.1703799.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a common infectious pathogen during stem cell trans-plantation. We report a case of meningoencephalitis with multiple abscess formation caused by MRSA, which occurred in a 4-year-old boy soon after allogeneic peripheral blood stem cell transplantation. We successfully cured the infection with a combination of intravenous and intrathecal vancomycin.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Child, Preschool
  • Humans
  • Infusions, Intravenous
  • Injections, Spinal
  • Leukemia, Myeloid, Acute / therapy*
  • Male
  • Meningoencephalitis / drug therapy*
  • Meningoencephalitis / etiology
  • Meningoencephalitis / microbiology
  • Methicillin Resistance
  • Neoplasms, Second Primary / therapy*
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / etiology
  • Staphylococcus aureus
  • Stem Cell Transplantation / adverse effects*
  • Transplantation, Homologous
  • Treatment Outcome
  • Vancomycin / administration & dosage
  • Vancomycin / therapeutic use*

Substances

  • Anti-Bacterial Agents
  • Vancomycin