Acute stent thrombosis after early withdrawal of platelet glycoprotein IIb/IIIa antagonists: potential rebound prothrombotic effect?

Catheter Cardiovasc Interv. 2003 Apr;58(4):481-4. doi: 10.1002/ccd.10452.

Abstract

We report on two cases of acute coronary stent thrombosis after early withdrawal of different competitive inhibitors of the platelet glycoprotein IIb/IIIa receptor, eptifibatide and tirofiban. Differences in pharmacokinetics between different types of glycoprotein IIb/IIIa receptor blockers and a potential rebound prothrombotic effect with the use of these antiplatelet drugs are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Angioplasty, Balloon, Coronary / adverse effects*
  • Angioplasty, Balloon, Coronary / methods
  • Catheterization / methods
  • Combined Modality Therapy
  • Coronary Angiography / methods
  • Coronary Restenosis / diagnostic imaging
  • Coronary Restenosis / therapy
  • Coronary Stenosis / diagnostic imaging
  • Coronary Stenosis / therapy*
  • Coronary Thrombosis / diagnostic imaging
  • Coronary Thrombosis / therapy*
  • Electrocardiography
  • Follow-Up Studies
  • Hematoma / diagnostic imaging
  • Hematoma / therapy
  • Humans
  • Male
  • Middle Aged
  • Peritoneal Diseases / diagnostic imaging
  • Peritoneal Diseases / therapy
  • Platelet Glycoprotein GPIIb-IIIa Complex / therapeutic use*
  • Risk Assessment
  • Severity of Illness Index
  • Stents / adverse effects*
  • Time Factors
  • Treatment Outcome

Substances

  • Platelet Glycoprotein GPIIb-IIIa Complex