Low-dose consecutive CDDP administrations have been reported to be effective in cancer treatment. We studied the inhibitory effects on pulmonary metastasis of bolus versus low-dose consecutive administration of CDDP chemotherapy for sarcoma-bearing mice, and evaluated the differences in responses to two types of therapy. Significant reductions (p < 0.01) in the number of pulmonary metastases were observed in the low-dose consecutive administration group compared to the control group, and in the bolus group compared to the control group. No significant difference in the number of metastases between the low-dose consecutive administration group and the bolus group was observed (p = 0.43). This study suggests that low-dose consecutive CDDP administration would be as effective as bolus CDDP administration, which is currently popular. Also, low-dose consecutive CDDP administrations may contribute to the attenuation of the adverse drug reactions expected by patients with bone and soft tissue tumors who are undergoing chemotherapy.