Objective: To study the mechanism of flavonoids from Semen Cuscutae (FSC) improving the ovarian endocrine functions.
Methods: (1) FSC were obtained from the semen of Cuscuta chinensis through solvent extraction and polyamide columnar chromatography. (2) Sound, light and electricity were combined into a stressful stimulas to induce psychologic stress in female rats. (3) To observe the effects of FSC on the changes of beta-EP in hypothalamuses, FSH and LH in anterior pituitaries and the changes in pituitary morphology in female rats exposed to psychologic stress.
Results: FSC decreased the content of beta-EP in hypothalamuses, and increased the numbers of basophilic cell and content of LH in anterior pituitaries, didn't change content of FSH in anterior pituitaries in female rats exposed to psychologic stress.
Conclusion: FSC decreases the contents of beta-EP in hypothalamuses and increases contents of LH in anterior pituitaries in female rats exposed to psychologic stress, which may be one of the mechanism of FSC improving hypothalamus-pituitary-ovary axis.