Adherence to highly active antiretroviral therapy is better in patients receiving non-nucleoside reverse transcriptase inhibitor-containing regimens than in those receiving protease inhibitor-containing regimens

AIDS. 2003 May 2;17(7):1099-102. doi: 10.1097/00002030-200305020-00026.

Abstract

The difference between adherence to non- nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI)-based regimens was investigated. Better adherence was found in NNRTI-treated patients, especially when efavirenz was included in the regimen, compared with single PI-treated patients and in those with CD4 cell counts less than 200 x 10(6)/l. By contrast, younger age, self-report of active drug use, fatigue or vomiting negatively affected adherence. Self-reported sexual dysfunction was significantly associated with non-adherence only in PI-treated individuals.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active
  • Cohort Studies
  • Fatigue / chemically induced
  • Female
  • HIV Infections / drug therapy*
  • HIV Protease Inhibitors / therapeutic use*
  • HIV Reverse Transcriptase / antagonists & inhibitors*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Patient Compliance*
  • Regression Analysis
  • Risk Factors
  • Sexual Dysfunction, Physiological / chemically induced
  • Substance-Related Disorders / complications
  • Surveys and Questionnaires
  • Vomiting / chemically induced

Substances

  • HIV Protease Inhibitors
  • HIV Reverse Transcriptase