Abstract
Here, we have demonstrated potent inhibition of allergen-mediated pulmonary inflammation and airway hyper-responsiveness by a novel dual-pronged action of LX's. Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Aspirin / pharmacology*
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Bronchi / drug effects*
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Bronchi / metabolism*
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Bronchi / pathology
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Bronchial Hyperreactivity / drug therapy
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Bronchial Hyperreactivity / metabolism*
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Bronchial Hyperreactivity / pathology
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Humans
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Hydroxyeicosatetraenoic Acids / administration & dosage
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Hydroxyeicosatetraenoic Acids / metabolism*
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Hydroxyeicosatetraenoic Acids / pharmacology*
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Inflammation / metabolism
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Inflammation / pathology
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Leukocytes / metabolism
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Lipoxins*
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Male
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Mice
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Mice, Inbred BALB C
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / metabolism
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Receptors, Formyl Peptide*
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Receptors, Lipoxin*
Substances
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FPR2 protein, human
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Hydroxyeicosatetraenoic Acids
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Lipoxins
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Receptors, Cell Surface
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Receptors, Formyl Peptide
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Receptors, Lipoxin
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lipoxin A4
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Aspirin