Lipoxins and aspirin-triggered lipoxins in airway responses

Adv Exp Med Biol. 2003:525:19-23. doi: 10.1007/978-1-4419-9194-2_5.

Abstract

Here, we have demonstrated potent inhibition of allergen-mediated pulmonary inflammation and airway hyper-responsiveness by a novel dual-pronged action of LX's. Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aspirin / pharmacology*
  • Bronchi / drug effects*
  • Bronchi / metabolism*
  • Bronchi / pathology
  • Bronchial Hyperreactivity / drug therapy
  • Bronchial Hyperreactivity / metabolism*
  • Bronchial Hyperreactivity / pathology
  • Humans
  • Hydroxyeicosatetraenoic Acids / administration & dosage
  • Hydroxyeicosatetraenoic Acids / metabolism*
  • Hydroxyeicosatetraenoic Acids / pharmacology*
  • Inflammation / metabolism
  • Inflammation / pathology
  • Leukocytes / metabolism
  • Lipoxins*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism
  • Receptors, Formyl Peptide*
  • Receptors, Lipoxin*

Substances

  • FPR2 protein, human
  • Hydroxyeicosatetraenoic Acids
  • Lipoxins
  • Receptors, Cell Surface
  • Receptors, Formyl Peptide
  • Receptors, Lipoxin
  • lipoxin A4
  • Aspirin