Stereocontrolled synthesis of ara-type cyclohexenyl nucleosides

J Org Chem. 2003 May 30;68(11):4499-505. doi: 10.1021/jo0300946.

Abstract

A highly stereocontrolled synthesis of a new class of carbocyclic nucleosides, ara-type cyclohexenyl nucleosides, was developed. The key intermediate (+/-)-9 was obtained after a series of transformations starting from easily available endo-bicyclo carboxylic acid (+/-)-3. The allylic hydroxyl group of (+/-)-9 was masked via oxidation with manganese dioxide and released, after protection of the 2'-hydroxyl group, via reduction with NaBH(4) in the presence of CeCl(3).7H(2)O. The base moiety was introduced with use of the Mitsunobu methodology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Acids / chemistry
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Cyclization
  • Indicators and Reagents
  • Molecular Structure
  • Nucleosides / chemical synthesis*
  • Oxidation-Reduction
  • Stereoisomerism

Substances

  • Carboxylic Acids
  • Indicators and Reagents
  • Nucleosides