Abstract
A series of new cyclohexenyl nucleosides is synthesized by coupling the heterocyclic bases with a protected cyclohexenyl precursor under Mitsunobu conditions. The compounds were evaluated for their antiviral and cytostatic activity. Pronounced activity against herpes simplex virus type 1 and type 2 was observed for the 2,6-diaminopurine analogue.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Antiviral Agents / toxicity
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Cell Division / drug effects
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Cell Line
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Cyclohexanes / chemistry
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Herpesvirus 1, Human / drug effects
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Herpesvirus 2, Human / drug effects
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Humans
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Microbial Sensitivity Tests
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Models, Chemical
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Nucleosides / chemical synthesis*
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Nucleosides / pharmacology*
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Structure-Activity Relationship
Substances
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Antiviral Agents
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Cyclohexanes
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Nucleosides