Abstract
Muscle biopsy findings in DM2 have been reported to be similar to those in DM1. The authors used myosin heavy chain immunohistochemistry and enzyme histochemistry for fiber type differentiation on muscle biopsies. Their results show that DM2 patients display a subpopulation of type 2 nuclear clump and other very small fibers and, hence, preferential type 2 fiber atrophy in contrast to type 1 fiber atrophy in DM1 patients.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Biopsy
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Diagnosis, Differential
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Female
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Muscle Fibers, Skeletal / pathology
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Muscle, Skeletal / pathology
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Myosin Heavy Chains / analysis
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Myosin Heavy Chains / immunology
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Myotonic Disorders / diagnosis
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Myotonic Disorders / pathology*
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Myotonic Dystrophy / diagnosis
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Myotonic Dystrophy / pathology*