Abstract
Myelin oligodendrocyte glycoprotein (MOG) is encoded within the RT1.M region of the rat MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis (EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG-EAE is associated with higher expression of MOG mRNA and protein in the nervous system than in the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune system, but there was no correlation with disease susceptibility. These results suggest that differences in the expression of MOG in the target organ, rather than in the immune system may influence susceptibility to MOG-EAE.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Axons / immunology
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Axons / metabolism
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Axons / pathology
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Base Sequence / genetics
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Disease Models, Animal
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Encephalomyelitis, Autoimmune, Experimental / genetics*
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Encephalomyelitis, Autoimmune, Experimental / immunology
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Female
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Genetic Predisposition to Disease / genetics*
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Genetic Variation / genetics*
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Genetic Variation / immunology
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Haplotypes
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Molecular Sequence Data
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Multiple Sclerosis / genetics*
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Multiple Sclerosis / immunology
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Myelin Proteins
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Myelin Sheath / genetics*
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Myelin Sheath / immunology
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Myelin Sheath / pathology
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Myelin-Associated Glycoprotein / genetics*
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Myelin-Associated Glycoprotein / immunology
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Myelin-Oligodendrocyte Glycoprotein
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Nervous System / immunology
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Nervous System / pathology
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Nervous System / physiopathology
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Polymorphism, Genetic / genetics
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RNA, Messenger / metabolism
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Rats
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Rats, Inbred Lew
Substances
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Mog protein, rat
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Myelin Proteins
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Myelin-Associated Glycoprotein
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Myelin-Oligodendrocyte Glycoprotein
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RNA, Messenger