Deformation of intracellular endosomes under a magnetic field

Eur Biophys J. 2003 Nov;32(7):655-60. doi: 10.1007/s00249-003-0312-0. Epub 2003 Jun 26.

Abstract

We present a non-invasive method to monitor the membrane tension of intracellular organelles using a magnetic field as an external control parameter. By exploiting the spontaneous endocytosis of anionic colloidal ferromagnetic nanoparticles, we obtain endosomes possessing a superparamagnetic lumen in eukaryotic cells. Initially flaccid, the endosomal membrane undulates because of thermal fluctuations, restricted in zero field by the resting tension and the curvature energy of the membrane. When submitted to a uniform magnetic field, the magnetized endosomes elongate along the field, resulting in the flattening of the entropic membrane undulations. The quantification of the endosome deformation for different magnetic fields allows in situ measurement of the resting tension and the bending stiffness of the membrane enclosing the intracellular organelle.

Publication types

  • Evaluation Study

MeSH terms

  • Cell Membrane / physiology
  • Cell Membrane / radiation effects*
  • Cell Membrane / ultrastructure*
  • Cell Size / physiology
  • Cell Size / radiation effects
  • Elasticity
  • Electromagnetic Fields*
  • Endosomes / physiology
  • Endosomes / radiation effects*
  • Endosomes / ultrastructure*
  • Ferric Compounds*
  • Mechanotransduction, Cellular / physiology
  • Membrane Fluidity / radiation effects*
  • Micromanipulation / instrumentation
  • Micromanipulation / methods*
  • Physical Stimulation
  • Stress, Mechanical

Substances

  • Ferric Compounds