By the end of the 20th century, the worldwide diabetes pandemic had affected an estimated 151 million persons. Strategies to mitigate both the human and economic burden are urgently needed. Efficacious treatments are currently available but the quality of diabetes care being delivered is suboptimal in both developed and developing countries. Some progress to improve quality has been made thought national strategies. These efforts need two elements: "translation" research that will establish the methods needed to assure that clinical research findings are delivered effectively in every day practice settings; and development and implementation of quality improvement measures that will reliably track progress. New interventions that prevent diabetes among those at high risk also now hold much promise and need to be implemented.