Abstract
Monotherapy of hepatitis C virus infection with either alpha interferon or ribavirin alone is rather ineffective, while the use of the two antivirals together is much more efficacious. In vitro drug-drug combination analysis utilizing related members of the family Flaviviridae, bovine viral diarrhea virus and yellow fever virus, revealed significant direct synergistic interactions between these drugs' antiviral activities that might explain this clinical observation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Cattle
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Cell Line
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Diarrhea Viruses, Bovine Viral / drug effects*
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Diarrhea Viruses, Bovine Viral / growth & development
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Drug Synergism
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Hepacivirus / growth & development*
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In Vitro Techniques
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Interferon-alpha / pharmacology*
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Ribavirin / pharmacology*
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Virus Replication / drug effects
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Yellow fever virus / drug effects*
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Yellow fever virus / growth & development
Substances
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Antiviral Agents
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Interferon-alpha
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Ribavirin