Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa

Antimicrob Agents Chemother. 2003 Jul;47(7):2313-5. doi: 10.1128/AAC.47.7.2313-2315.2003.

Abstract

The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbapenems / pharmacology*
  • Drug Resistance, Bacterial
  • Latex
  • Microbial Sensitivity Tests
  • Porins / biosynthesis*
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / growth & development
  • Pseudomonas aeruginosa / metabolism
  • Silicon
  • Urinary Catheterization / adverse effects*
  • Zinc / pharmacology*

Substances

  • Carbapenems
  • Latex
  • Porins
  • OprD protein, Pseudomonas aeruginosa
  • Zinc
  • Silicon