A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors

Bioorg Med Chem Lett. 2003 Jul 21;13(14):2255-9. doi: 10.1016/s0960-894x(03)00462-1.

Abstract

A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of the coagulation cascade serine protease factor Xa.

MeSH terms

  • Factor Xa Inhibitors*
  • Glycine / analogs & derivatives*
  • Glycine / chemical synthesis*
  • Glycine / pharmacology*
  • Indicators and Reagents
  • Serine Proteinase Inhibitors / chemical synthesis*
  • Serine Proteinase Inhibitors / pharmacology*
  • Structure-Activity Relationship

Substances

  • Factor Xa Inhibitors
  • Indicators and Reagents
  • Serine Proteinase Inhibitors
  • phenylglycinamide
  • Glycine