Abstract
cDNA clones for a human HOX 7 gene obtained with homologous clones of Drosophila were used in human gene mapping studies. The human cDNA clone was isolated from a library constructed from human embryonic craniofacial material. The sequence of the cDNA demonstrates significant homology with mouse HOX 7. A search for RFLPs identified MboII and BstEII variants. A CA dinucleotide repeat with 5 alleles was also identified and allowed placement of HOX 7 into a defined linkage map. Evidence for linkage disequilibrium was found with markers tested. These results place the human HOX 7 gene in a defined position on 4p.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Mapping / methods
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Chromosomes, Human, Pair 4*
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Cloning, Molecular / methods
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DNA / genetics*
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DNA / isolation & purification
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Deoxyribonucleases, Type II Site-Specific
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Drosophila / genetics
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Embryo, Mammalian
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Embryo, Nonmammalian
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Female
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Gene Library
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Genes, Homeobox*
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Genetic Variation
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Humans
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Linkage Disequilibrium
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Male
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Molecular Sequence Data
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Oligodeoxyribonucleotides
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Pedigree
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Polymorphism, Restriction Fragment Length*
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RNA / genetics
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RNA / isolation & purification
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Restriction Mapping
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Sequence Homology, Nucleic Acid
Substances
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Oligodeoxyribonucleotides
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RNA
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DNA
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endodeoxyribonuclease MboII
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Deoxyribonucleases, Type II Site-Specific
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GGTNACC-specific type II deoxyribonucleases
Associated data
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GENBANK/M88632
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GENBANK/M88633
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GENBANK/M88634
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GENBANK/M88635
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GENBANK/M88636
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GENBANK/M88637
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GENBANK/M97676
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GENBANK/X64597
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GENBANK/X64598
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GENBANK/X64599