Phenolic constituents from Dalbergia cochinchinensis

Osamu Shirota; Vibha Pathak; Setsuko Sekita; Motoyoshi Satake; Yoshio Nagashima; Yutaka Hirayama; Yusuke Hakamata; Tatsuo Hayashi

doi:10.1021/np0300683

Phenolic constituents from Dalbergia cochinchinensis

J Nat Prod. 2003 Aug;66(8):1128-31. doi: 10.1021/np0300683.

Authors

Osamu Shirota¹, Vibha Pathak, Setsuko Sekita, Motoyoshi Satake, Yoshio Nagashima, Yutaka Hirayama, Yusuke Hakamata, Tatsuo Hayashi

Affiliation

¹ Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. shirota@nihs.go.jp

PMID: 12932142
DOI: 10.1021/np0300683

Abstract

Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectroscopic techniques including 1D and 2D NMR methods. The inhibitory activity against testosterone 5 alpha-reductase, which causes androgen-dependent diseases, was also examined for selected compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5-alpha Reductase Inhibitors*
Androgen Antagonists / chemistry
Androgen Antagonists / isolation & purification*
Androgen Antagonists / pharmacology
Dalbergia / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phenols / chemistry
Phenols / isolation & purification*
Phenols / pharmacology
Plant Stems / chemistry
Plants, Medicinal / chemistry*
Vietnam

Substances

5-alpha Reductase Inhibitors
Androgen Antagonists
Phenols