Therapeutic applications in the chemokine superfamily

Curr Opin Chem Biol. 2003 Aug;7(4):457-60. doi: 10.1016/s1367-5931(03)00086-3.

Abstract

The chemokine superfamily is probably complete. There are 42 human chemokines that through interaction with 18 receptors (which belong to the GPCR superfamily-class A) play pivotal roles in many important human diseases. Here we review some of the most compelling opportunities for drug development in this area.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Animals
  • Antibodies / immunology
  • Antibody Formation / immunology
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Neoplasm
  • CCR5 Receptor Antagonists
  • Chemokine CX3CL1
  • Chemokine CXCL13
  • Chemokines / immunology
  • Chemokines / therapeutic use*
  • Chemokines, CX3C / immunology
  • Chemokines, CXC / immunology
  • Drug Design
  • Humans
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Interleukin-1 / immunology
  • Ligands
  • Membrane Glycoproteins / immunology
  • Membrane Proteins / immunology
  • Neoplasms / drug therapy
  • Neoplasms / immunology
  • Receptors, Chemokine / agonists*
  • Receptors, Chemokine / antagonists & inhibitors*

Substances

  • Adjuvants, Immunologic
  • Antibodies
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Neoplasm
  • CCR5 Receptor Antagonists
  • CTAGE1 protein, human
  • CX3CL1 protein, human
  • CXCL13 protein, human
  • Chemokine CX3CL1
  • Chemokine CXCL13
  • Chemokines
  • Chemokines, CX3C
  • Chemokines, CXC
  • Interleukin-1
  • Ligands
  • Membrane Glycoproteins
  • Membrane Proteins
  • Receptors, Chemokine