Non-covalent stabilization of a beta-hairpin peptide into liposomes

Org Biomol Chem. 2003 Jun 7;1(11):1827-9. doi: 10.1039/b303749e.

Abstract

An oligopeptide modified on both the N- and C-termini with hydrophobic moieties was prepared on a solid phase and anchored into a liposome, stabilizing the fold of the peptide into a beta-hairpin, which would otherwise be a random coil.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Circular Dichroism
  • Liposomes / chemistry*
  • Models, Molecular
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry*
  • Phosphatidylcholines / chemistry
  • Plasmodium falciparum
  • Pressure
  • Protein Structure, Secondary
  • Protozoan Proteins / genetics

Substances

  • Liposomes
  • Oligopeptides
  • Phosphatidylcholines
  • Protozoan Proteins