Detection of human papillomavirus DNA sequences in tongue squamous-cell carcinoma utilizing the polymerase chain reaction method

Int J Cancer. 1992 Jan 21;50(2):167-71. doi: 10.1002/ijc.2910500202.

Abstract

Twenty-four cases of tongue squamous-cell carcinoma (SCC) were analyzed for human papillomavirus (HPV) DNAs by the polymerase chain reaction (PCR) method and the dot-blot hybridization technique. HPV DNAs were detected in 8 cases. One specimen histopathologically diagnosed as poorly differentiated grade-III SCC contained both HPV-16 and HPV-18 DNA, and 7 other cases contained HPV-16 DNA.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence
  • Carcinoma, Squamous Cell / complications
  • Carcinoma, Squamous Cell / microbiology*
  • Carcinoma, Squamous Cell / pathology
  • DNA, Viral / analysis*
  • DNA, Viral / genetics
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Papillomaviridae / genetics*
  • Polymerase Chain Reaction / statistics & numerical data*
  • Tongue Neoplasms / complications
  • Tongue Neoplasms / microbiology*
  • Tongue Neoplasms / pathology
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / genetics*

Substances

  • DNA, Viral