The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

Science. 1992 Feb 21;255(5047):989-91. doi: 10.1126/science.1312256.

Abstract

The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cloning, Molecular
  • Cross-Linking Reagents
  • Endothelial Growth Factors / physiology*
  • Enzyme Activation
  • Humans
  • In Vitro Techniques
  • Lymphokines / physiology*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*
  • Receptors, Cell Surface / genetics*
  • Signal Transduction
  • Transfection
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Endothelial Growth Factors
  • Xenopus laevis

Substances

  • Cross-Linking Reagents
  • Endothelial Growth Factors
  • Lymphokines
  • Proto-Oncogene Proteins
  • Receptors, Cell Surface
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Vascular Endothelial Growth Factor Receptor-1