Local injections of granulocyte-macrophage colony-stimulating factor (Gm-CSF) for the treatment of radiation-induced mucosa ulcers

Radiother Oncol. 2003 Sep;68(3):303-4. doi: 10.1016/s0167-8140(03)00060-4.

Abstract

We report two cases illustrating how Gm-CSF can facilitate rapid and persistent healing of ulcers associated with contact radiation therapy. This simple and safe method should be proposed for the treatment of chronic ulcers that develop in a formerly radiated zone.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Brachytherapy / adverse effects*
  • Carcinoma, Squamous Cell / radiotherapy
  • Chronic Disease
  • Esophageal Diseases / drug therapy*
  • Esophageal Diseases / etiology
  • Esophageal Neoplasms / radiotherapy
  • Esophagus / drug effects*
  • Esophagus / radiation effects*
  • Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage
  • Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use*
  • Humans
  • Injections, Intralesional
  • Male
  • Middle Aged
  • Treatment Outcome
  • Ulcer / drug therapy*
  • Ulcer / etiology

Substances

  • Granulocyte-Macrophage Colony-Stimulating Factor