Expressions of receptor gene for hepatocyte growth factor in kidney after unilateral nephrectomy and renal injury

Biochem Biophys Res Commun. 1992 Sep 30;187(3):1454-9. doi: 10.1016/0006-291x(92)90465-w.

Abstract

The renal expressions of the receptor gene (c-met) for hepatocyte growth factor (HGF) were examined in unilateral nephrectomy (UNX), renal ischemia or folic acid administration. The levels of c-met mRNA were increased rapidly in all rat models at 6h after the operations. On the other hand, the expression of c-met mRNA in a kidney cell line (MDCK cells) was down-regulated for 8 h after HGF addition, indicating that c-met mRNA induction in rat models may be independent of the stimulated production of HGF. The stimulated expression of c-met in these models suggest that HGF may play an important role in renal hypertrophy after UNX and regeneration after ischemic or nephrotoxic injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Folic Acid / pharmacology
  • Gene Expression / drug effects
  • Hepatocyte Growth Factor / pharmacology*
  • Ischemia / genetics
  • Kidney / blood supply
  • Kidney / injuries
  • Kidney / physiology*
  • Male
  • Nephrectomy
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-met
  • Proto-Oncogenes
  • RNA, Messenger / genetics
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cell Surface / genetics*
  • Time Factors

Substances

  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • Hepatocyte Growth Factor
  • Folic Acid
  • Proto-Oncogene Proteins c-met