Peripheral T-cell lymphoma involving the placenta

Cancer. 1992 Dec 15;70(12):2963-8. doi: 10.1002/1097-0142(19921215)70:12<2963::aid-cncr2820701238>3.0.co;2-v.

Abstract

Background: Placental involvement by maternal malignant lymphoma is a rare complication of pregnancy.

Methods: The case of a 29-year-old woman found to have placental involvement by peripheral T-cell lymphoma (PTCL) diagnosed by morphologic study, immunoperoxidase stains, and molecular genetic studies is reported.

Results: The lymphoma was pathologic Stage IVB and although there were no adverse consequences for the child, but the neoplasm progressed rapidly during the postpartum period.

Conclusions: The clinical course suggested that the immunologic changes of the pregnancy exerted a lymphoma-suppressive effect on the lymphoma. The authors know of no other report of a patient with placental involvement by PTCL.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD / analysis
  • Female
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / physiology
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / physiology
  • Humans
  • Immunohistochemistry
  • Lymphoma, Non-Hodgkin / genetics
  • Lymphoma, Non-Hodgkin / immunology
  • Lymphoma, Non-Hodgkin / pathology*
  • Lymphoma, T-Cell, Peripheral / genetics
  • Lymphoma, T-Cell, Peripheral / immunology
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Placenta Diseases / genetics
  • Placenta Diseases / immunology
  • Placenta Diseases / pathology*
  • Postpartum Period
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Pregnancy
  • Pregnancy Complications, Neoplastic / immunology
  • Pregnancy Complications, Neoplastic / pathology*
  • Pregnancy Complications, Neoplastic / physiopathology

Substances

  • Antigens, CD