Immunization with fimbrial protein and peptide protects against Porphyromonas gingivalis-induced periodontal tissue destruction

Adv Exp Med Biol. 1992:327:255-62. doi: 10.1007/978-1-4615-3410-5_27.

Abstract

In these studies we have attempted to show that cell surface structures are critical antigens for protection against P. gingivalis-induced periodontal destruction. Fimbrillin, and in particular a synthetic 20-amino-acid fimbrillin peptide, exerts a protective effect in gnotobiotic rats, thus identifying them as potentially useful in the development of a vaccine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alveolar Bone Loss / immunology
  • Alveolar Bone Loss / prevention & control
  • Animals
  • Antibodies, Bacterial / biosynthesis
  • Antibodies, Bacterial / blood
  • Bacterial Proteins / immunology*
  • Bacteroides Infections / immunology
  • Bacteroides Infections / prevention & control*
  • Fimbriae, Bacterial / immunology*
  • Gingiva / immunology
  • Male
  • Peptides / immunology*
  • Periodontal Diseases / immunology
  • Periodontal Diseases / prevention & control*
  • Porphyromonas gingivalis / immunology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Antibodies, Bacterial
  • Bacterial Proteins
  • Peptides