Abstract
Interferon (IFN) is capable of modulating the cytotoxic effects and clinical activity of the fluorinated pyrimidine, 5-fluorouracil (5-FU). This occurs in the absence of a demonstrable effect on immune function, suggesting that these effects occur at the biochemical level. Pharmacokinetic studies have also demonstrated that IFN can increase serum levels of 5-FU. The relative importance of these effects on enhancement of 5-FU activity remains to be investigated.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Clinical Trials as Topic
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Drug Evaluation
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Drug Screening Assays, Antitumor
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Fluorouracil / pharmacokinetics
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Fluorouracil / therapeutic use
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Humans
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Interferons / administration & dosage
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Interferons / pharmacokinetics
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Interferons / pharmacology