Ion channel activity and transmembrane signaling in lymphocytes

Ann N Y Acad Sci. 1992 Apr 15:650:205-10. doi: 10.1111/j.1749-6632.1992.tb49123.x.

Abstract

Transmembrane signalling refers to the process of transfer of information from the extracellular world into the intracellular space. The information is transduced through several possible pathways. The significance of cell surface dynamics, ion channel activity and drug effects are discussed in the signal transmission, with special reference to Na+ channels and the Ca2+ sensitive potassium channels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bretylium Tosylate / pharmacology
  • Cell Membrane / physiology
  • Cyclosporine / pharmacology
  • Humans
  • Ion Channel Gating
  • Ion Channels / physiology*
  • Lymphocyte Activation
  • Lymphocytes / physiology*
  • Membrane Potentials
  • Second Messenger Systems
  • Signal Transduction / drug effects

Substances

  • Ion Channels
  • Bretylium Tosylate
  • Cyclosporine