The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglII

Genes Chromosomes Cancer. 1992 Jan;4(1):84-8. doi: 10.1002/gcc.2870040113.

Abstract

The NM23-Hl gene is a putative tumor suppressor gene that may be important in the metastasic process. Recent genetic and immunological data indicate that the NM23-Hl gene encodes a protein with nucleoside diphosphate (NDP) kinase activity. The mapping of NM23-Hl by panels of rodent-human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two-allele polymorphism with BglII was demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Bacterial Proteins*
  • Blotting, Southern
  • Breast Neoplasms / genetics
  • Chromosome Mapping
  • Chromosomes, Human, Pair 17*
  • Cricetinae
  • DNA / genetics
  • Deoxyribonucleases, Type II Site-Specific
  • Genes, Tumor Suppressor*
  • Genetic Predisposition to Disease
  • Humans
  • Hybrid Cells / ultrastructure
  • Monomeric GTP-Binding Proteins*
  • NM23 Nucleoside Diphosphate Kinases
  • Nucleic Acid Hybridization
  • Nucleoside-Diphosphate Kinase*
  • Polymorphism, Restriction Fragment Length
  • Proteins / genetics
  • Transcription Factors*

Substances

  • Bacterial Proteins
  • NM23 Nucleoside Diphosphate Kinases
  • Proteins
  • Transcription Factors
  • DNA
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
  • BglII endonuclease
  • Deoxyribonucleases, Type II Site-Specific
  • Monomeric GTP-Binding Proteins