Dynamics of gastric emptying during and after stomach fill

Am J Physiol. 1992 Oct;263(4 Pt 2):R813-9. doi: 10.1152/ajpregu.1992.263.4.R813.

Abstract

Gastric contents were sampled at various points during and after intragastric infusions of glucose solution (6.25, 12.5, 25%) delivered at rates typical of normal ingestion in the rat. The postinfusion results were consistent with those reported in the literature in that glucose solute emptied at a relatively stable rate over time and across stimulus concentrations. During fill (1.0 ml/min; experiment 1), by contrast, solute (caloric) emptying rate increased about threefold as stimulus concentration was raised. For each concentration, emptying rate was uniformly higher during than after fill (approximately 4 times higher at the lowest concentration). In experiment 2, gastric emptying rate during 12-min intragastric infusions of 12.5% glucose varied directly with the volumetric rate (0.5, 1.0, 2.0 ml/min) at which they were delivered. These results show that different rules govern gastric emptying during and after stomach fill. The results also suggest that a large proportion of a liquid meal may empty before feeding is terminated and that variations in the rate of ingestion could affect the gastric/postgastric distribution of ingesta and, in turn, the satiation process.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Animals
  • Drinking*
  • Gastric Emptying / physiology*
  • Gastrointestinal Contents / chemistry
  • Glucose / analysis
  • Infusion Pumps
  • Male
  • Osmolar Concentration
  • Rats
  • Rats, Sprague-Dawley
  • Solutions

Substances

  • Solutions
  • Glucose