URACIL MUSTARD: A POTENT INDUCER OF LUNG TUMORS IN MICE

Science. 1965 Mar 19;147(3664):1443-5. doi: 10.1126/science.147.3664.1443.

Abstract

Uracil mustard, injected intraperitoneally, increased the incidence and average number of pulmonary tumors in A/J mice. In comparison to a typical alkylating agent, nitrogen mustard, or to urethan, uracil mustard (on a molar basis) was considerably more carcinogenic.

MeSH terms

  • DNA*
  • Lung Neoplasms*
  • Mechlorethamine*
  • Mice
  • Neoplasms*
  • Neoplasms, Experimental*
  • Nitrogen Mustard Compounds*
  • Pharmacology*
  • RNA*
  • Research*
  • Toxicology*
  • Uracil Mustard*
  • Urethane*

Substances

  • Nitrogen Mustard Compounds
  • Urethane
  • Mechlorethamine
  • RNA
  • DNA
  • Uracil Mustard