The role of the rat submandibular gland in the excretion of bis (tributyltin) oxide: electron microscopy, X-ray microanalysis and atomic absorption analysis

M Yoshizuka; K Hara; N Nagata; Y Doi; M Yokoyama; T Sagara; S Fujimoto

doi:10.1016/0040-8166(92)90044-8

The role of the rat submandibular gland in the excretion of bis (tributyltin) oxide: electron microscopy, X-ray microanalysis and atomic absorption analysis

Tissue Cell. 1992;24(5):725-33. doi: 10.1016/0040-8166(92)90044-8.

Authors

M Yoshizuka¹, K Hara, N Nagata, Y Doi, M Yokoyama, T Sagara, S Fujimoto

Affiliation

¹ Department of Anatomy, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.

PMID: 1440590
DOI: 10.1016/0040-8166(92)90044-8

Abstract

The role of the submandibular glands in the excretion of parenterally administered bis (tributyltin) oxide (TBTO) was studied. Fine structural alterations of the submandibular glands were observed with an electron microscope. Accumulation sites of TBTO were determined with an X-ray microanalyzer and tin concentrations in saliva and blood were measured by atomic absorption spectrophotometry.

MeSH terms

Animals
Electron Probe Microanalysis
Male
Microscopy, Electron
Rats
Rats, Wistar
Saliva / chemistry
Spectrophotometry, Atomic
Submandibular Gland / drug effects
Submandibular Gland / metabolism*
Submandibular Gland / ultrastructure
Tin / analysis
Tin / blood
Trialkyltin Compounds / metabolism*
Trialkyltin Compounds / pharmacology

Substances

Trialkyltin Compounds
bis(tri-n-butyltin)oxide
Tin