Successful hematopoietic stem cell transplantation for Fanconi anemia from an unaffected HLA-genotype-identical sibling selected using preimplantation genetic diagnosis

Blood. 2004 Feb 1;103(3):1147-51. doi: 10.1182/blood-2003-02-0587. Epub 2003 Sep 22.

Abstract

The only proven cure for Fanconi anemia (FA)-associated bone marrow failure is successful allogeneic hematopoietic stem cell transplantation (HSCT). However, HSCT with donors other than HLA-identical siblings is associated with high morbidity and poor survival. Therefore, we used preimplantation genetic diagnosis (PGD) to select an embryo produced by in vitro fertilization (IVF) that was unaffected by FA and was HLA-identical to the proband. The patient was a 6-year-old girl with FA and myelodysplasia previously treated with oxymetholone and prednisone. After her parents underwent 5 cycles of IVF with intrauterine transfer of 7 embryos over a span of 4 years, successful pregnancy ensued. Twenty-eight days after delivery, the patient underwent transplantation with her newborn sibling donor's HLA-identical umbilical cord blood hematopoietic stem cells (HSCs). Neutrophil recovery occurred on day 17 without subsequent acute or chronic graft-versus-host disease. Currently, 2.5 years after transplantation, the patient is well and hematopoiesis is normal. In summary, we have described the first successful transplantation, using IVF and PGD, of HSCs from a donor selected on the basis of specific, desirable disease and HLA characteristics. The medical, legal, and ethical issues involved with this approach are discussed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Fanconi Anemia / genetics
  • Fanconi Anemia / immunology*
  • Fanconi Anemia / therapy*
  • Female
  • Fertilization in Vitro
  • Fetal Blood / cytology
  • Fetal Blood / transplantation
  • Genetic Testing / ethics
  • Genetic Testing / methods*
  • Genotype
  • HLA Antigens / genetics*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Infant, Newborn
  • Living Donors / ethics
  • Male
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / immunology
  • Myelodysplastic Syndromes / therapy
  • Pregnancy
  • Prenatal Diagnosis / ethics
  • Prenatal Diagnosis / methods
  • Siblings

Substances

  • HLA Antigens