Abstract
Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic PD in a Finnish case-control series. This gene does not play a major role in the genetic predisposition to PD in this population.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Alleles
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DNA Mutational Analysis
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Female
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Finland / epidemiology
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Genetic Predisposition to Disease
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Genetic Testing
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Genotype
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Humans
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Intracellular Signaling Peptides and Proteins
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Male
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Middle Aged
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Oncogene Proteins / genetics*
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Parkinson Disease / epidemiology
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Parkinson Disease / genetics*
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Polymorphism, Genetic / genetics*
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Protein Deglycase DJ-1
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Risk Assessment
Substances
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Intracellular Signaling Peptides and Proteins
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Oncogene Proteins
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PARK7 protein, human
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Protein Deglycase DJ-1