Protein surface recognition by rational design: nanomolar ligands for potassium channels

J Am Chem Soc. 2003 Oct 22;125(42):12668-9. doi: 10.1021/ja036155z.

Abstract

The rational design and development of four-fold symmetrical ligands for potassium channels is described.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / metabolism
  • Binding, Competitive
  • Kinetics
  • Ligands
  • Molecular Sequence Data
  • Porphyrins / chemistry
  • Porphyrins / metabolism
  • Porphyrins / pharmacology
  • Potassium Channel Blockers / chemistry
  • Potassium Channel Blockers / metabolism
  • Potassium Channel Blockers / pharmacology
  • Potassium Channels / chemistry*
  • Potassium Channels / metabolism
  • Shaker Superfamily of Potassium Channels
  • Surface Properties
  • Xenopus

Substances

  • Bacterial Proteins
  • Ligands
  • Porphyrins
  • Potassium Channel Blockers
  • Potassium Channels
  • Shaker Superfamily of Potassium Channels
  • prokaryotic potassium channel